This mission carried human muscle cells from 7 human donors in order to explore their growth and behavior.
Experiments for Israeli and Italian academies
Four experiments in biology and biochemistry will be performed.
Bacterial conjugation, dissemination of antibiotic resistance genes and their expression control under microgravity conditions
Study the effect of microgravity and low fluid shear on the acquisition of antibiotic resistance via conjugation and determine how microgravity affects the transcriptional landscape of virulence and conjugation genes in clinically important pathogens
Reconfiguration of DNA structures and their functions under no gravity conditions
Identifying the effect of µ-gravity conditions on the:
1. self-assembly of G-quadruplexes
2. catalytic functions of the hemin/G-quadruplexes
Enzymatic Reactions with Bacteria in micro-Gravity
Investigate how the microgravity environment of space affects the kinetics of the action of antimicrobial agents on bacterial pathogens
Microgravity effects on human serum albumin binding properties
Investigate the heme binding to HSA in microgravity conditions as a prototypical model to establish whether gravity may affect the HSA capability to bind endogenous and exogenous molecule
Experiments for Science classes from schools in Israel
M&M – Metformin and Muscles - Human Skeletal Muscles Satellite Cells (HSkMC) in microgravity
Two main questions:
1. How does microgravity affect the regeneration process of human muscle cells and specifically the behavior of satellite cells?
2. How does Metformin effect on human muscle cells that went through regeneration in microgravity?
Effect of Microgravity on Motor Neurons
What are the effects of microgravity on gene expression in the destruction process of motor neurons cells?
Effect of microgravity on Enzymes secretion from Pancreas Acinar Cells
What are the effects of microgravity on Lipase and Amylase secretion levels in Acinar cells?